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Closer to soup

Back about a million years ago, the Lipton Soup Company ran a television commercial where an annoying kid kept asking his mother, “Is it soup yet?”

That’s the same sort of question genetic genealogists have been asking about the so-called admixture reports in our DNA test results. Those are the estimates by the various DNA testing laboratories and companies of what percentage of your ancestry can be traced to specific parts of the world.

The simple fact is, it’s not soup yet. But it’s getting closer every day, and things took a big step forward this week when the testing company 23andMe presented its new Ancestry Composition feature, with lots of options for looking at your admixture results.

Before this new system, my 23andMe admixture results were… well… frankly disappointing.

I mean, really. 100% European. How boring can you get!

And when I first looked at the new system, I was still… well… frankly disappointed.

Oh, joy. I’ve “improved” all the way from 100% European to (gasp) 99.4% European, picking up 0.2% sub-Saharan African and 0.4% who-the-hell-knows in the mix.

And then I started playing with all the options.

The first thing you can tell the system to do is break your admixture down to the smallest segments it can. And that gives me a little more information.

Now that’s a little better. I’m still 80.6% somewhere-in-Europe but I’ve picked up 9.4% British and Irish, 6.4% French and German, 1.4% Scandinavia, 0.5% Eastern European and less than 0.1% Askenazi Jewish to go along with my 0.2% sub-Saharan African and 0.4% who-the-hell-knows.

Then I decided to let ‘er rip. There’s an option to let the algorithm behind the admixture speculate. And that gave me this:

Better still. Now I’m 36.4% somewhere-in-northern-Europe, 1.2% somewhere-in-southern-Europe, and 2.7% somewhere-generally-in-Europe, 25.8% British and Irish, 26.0% French and German, 5.8% Scandinavia, 1.1% Italian, 0.6% Eastern European, less than 0.1% Askenazi Jewish, and 0.2% sub-Saharan African and only 0.1% who-the-hell-knows.

Generally speaking, the results look pretty good overall. Folks who know a great deal more about this than I do say this is a major move in the right direction, and it certainly appears to reflect major chunks of my known heritage.

So why isn’t it soup? Because there’s a lot we still don’t know, and some things even this admixture system reports than just don’t make sense.

Take, for example, my X chromosome results. The new Ancestry Composition says my X DNA is entirely European but identifies none of my X DNA as French-German.

Now I got one entire X chromosome from my German-born father. He inherited it lock stock and barrel from his German-born mother. She got one of her X chromosomes from her German-born father (who got it lock stock and barrel from his German-born mother and so forth) and the other from her German-born mother who inherited from her German-born parents (and so forth). I have literally hundreds of documented years of nothing but Germans on my father’s side.

So why isn’t roughly one-half of my X DNA being detected as French-German? I don’t know.

I’d write this off as just an anomaly of the algorithm — that maybe the software can’t read French-German in the X chromosome region — except that I have a nephew, my sister’s son, who has also tested with 23andMe. Being male, he has only one X chromosome, and he inherited that solely from his mother.

Now it’s certainly possible that she and I got very different X DNA bits and pieces on the X chromosome we each got from our mother, since it would be a mix of the X DNA from our maternal grandparents. But one of the X chromosomes each of us received has got to be identical: our father only had one X chromosome to give to his daughters.

My nephew’s one X chromosome would be a mix of the X DNA from both of his maternal grandparents, my sister’s and my parents. So he should have about 50% from our mother and 50% from our father. Since I have twice as much X chromosome real estate as he has, you’d figure about 25% of my total X DNA would match him. Moreover, since all of his X DNA came from his mother, anything he has that’s French-German is X DNA I have to have too.

And we do share huge portions of our X DNA: about 110 centiMorgans, as a matter of fact, and graphically it looks like this:

But when our two sets of results get analyzed in the Ancestry Composition system — granted at the speculative level, his X DNA shows up with a big chunk of French-German (shown below in yellow for contrast) and mine doesn’t show any at all:

No question it’s hard to distinguish one European population from another, and there’s no doubt this whole admixture area is a work in progress. Things are bound to improve and, perhaps, when the data from the new Geno 2.0 test from National Geographic is added to the mix, we’ll get this nailed down someday.

But for now…


Not soup yet.

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